In recent years Genetic Algorithms (GA) and Artificial Neural Network (ANN) is increasingly becoming increasingly important among the techniques routinely used in chemometrics. This is followed by application chapters in which special emphasis will be given to benefit from the application of GA or ANN to a specific problem, compared with classical techniques, and risks associated with abuse. - The subject of increasing importance - Comparison of Genetic Algorithm (GA) and Artificial Neural Network (ANN) with classical techniques - Suitable for beginners and advanced researchers