We have all their debts. "-Eric Lander from the Foreword Reviews of First Edition "... Provides a broad picture of the basic tools for sequence analysis ... For biologists approaching this subject for the first time, it will be a very useful book to keep on the shelf after the first reading, close to the computer.", Nature Structural Biology "... Must be in the personal library of any biologist who uses the Internet for analysis of DNA and protein sequence data." an excellent reference to the principles of bioinformatics "Trends in Biochemical Sciences. The new edition of the highly successful Bioinformatics: A Practical Guide for Analysis of Genes and Proteins provides the foundation of basic concepts, with practical discussion and comparison between the two computing devices and databases relevant to biological research. Completing a biologist with the modern equipment needed to solve practical problems in the analysis of sequence data, Second Edition covers a wide spectrum of topics in bioinformatics, ranging from the concept of the Internet for prediction algorithms used in sequence, structure, and expression data. Written in clear, simple language, the book accessible to users who do not have the background of the progress of mathematics or computer science. This new edition includes: * All-new end-chapter Web resources, bibliographies, and sets of problems * Accompanying Web site that contains answers to the problems, as well as links to relevant Web resources * New coverage of comparative genomics, large-scale genome analysis, assembly sequence, and expressed sequence tags * A glossary of terms commonly used in bioinformatics and genomics Bioinformatics: A Practical Guide for the Analysis of Genes and Proteins, Second Edition is essential reading for researchers, instructors, and students of all levels in the molecular biology and bioinformatics, as well as researchers involved in genomics, cloning positions, clinical research, and computational biology.