This conference proceedings of the International Conference on Systems, Computer Science and Software Engineering as well as a set of stringent review of world-class manuscripts addressing and detailing state-projects--the-art research in Computer Science, Software Engineering, Computer Engineering, and Systems Engineering and Science. International Conference on Systems, Computer Science and Software Engineering (SCSS 2005) was part of the Joint International Conference on Computer, Information and System Science and Technology (Cisse 2005). Cisse, 2005, World's first Engineering / Computing and Systems Research E-Conference first high-caliber Research Conference in the world should really be done online in real-time via the Internet. Cisse received 255 research paper submissions and the final program included 140 accepted papers, from more than 45 countries. Suffice it to say that Cisse receives input from more than 50 countries, the researchers, this opportunity presented a show far more affordable, dynamic and planned to attend and submit their work, versus a classic, conferences in the field. Cisse conference room audio provided exceptional audio even over low speed internet connections, the ability to display PowerPoint presentations, and cross-platform compatibility (the conferencing software runs on Windows, Mac, and any other operating system that supports Java). In addition, the conferencing system allowed for an unlimited number of participants, which in turn Cisse is given the opportunity to allow all participants to attend all presentations, as opposed to limiting the number of seats available for each session. Implemented conferencing technology, starting with the submission and review system and ending with the online conferencing capability, allowed Cisse to perform very high quality, fulfilling event for all participants.