This book provides a blueprint simultaneously design, user guide, research agenda, and communication platform for current development and future of artificial intelligence (AI) approach to systems biology. This places emphasis on the molecular dimension of life phenomena and in a chapter on modeling and functional brain anatomy. As design blueprint, the book is intended for scientists and other professionals in charge of developing and using AI technologies in the context of life science research. As a user guide, this book discusses the requirements for researchers to gain a basic understanding of key AI research methodology for the life sciences. As a research agenda, this book is aimed at students of computer science and life, teachers, researchers, and managers who want to understand the state of the art methodology is presented and areas where knowledge gaps demand further research and development of our.