Instinctive computing is a computational simulation of biological and cognitive instinct, which affects how we see, feel, appear, think and act. If we want computers that have to be really secure, intelligent, and interact naturally with us, we must give computers the ability to recognize, understand, and even to have a primitive instinct. This book, Computation with the Instinct, made up of the process of Instinctive Computing Workshop held at Carnegie Mellon University in the summer of 2009. This book consists of three parts: Instinctive Sensing, Communication and Environment, including new experiments with in vitro biological neurons to control robot cars, voice recognition is instinctive, vision, texture, visual abstraction, genre in culture, human interaction with the virtual world, intuitive interface, exploitative interactions, and agents for intelligent environments.