Semantic Grid: Model, Methodology, and Application to introduce to science, the core technology, and killer applications. First, the scientific issues covered semantic grid system, followed by two basic technical problems, data-level semantic mapping, and interoperating service level semantics. Two killer application then introduced to show how to build a semantic box for a particular application domain. He proposed the first clutch of knowledge represents a model, Couplingua, which embodies the Rule, Frames, Semantic Networks and Neural Network Cells, and support symbolic computation and computational data processing.